The Journal of Vitaminology 11, 234-238 (1965) Conditions for Thiaminic Acid Formation1

نویسندگان

  • ISAMU UTSUMI
  • KIYOSHI HARADA
  • GORO TSUKAMOTO
  • ISAMU DAIRA
چکیده

In the previous paper (1), thiaminic acid (TnA), a new oxidation product of thiamine , was reported to be easily formed through oxidation of thiol-type thiamine derivatives by H2O2 in an acetic acid solution. The thiol-type thiamine derivatives which induce TnA were shown to be the compounds which are readily converted to free thiamine by the reaction with thiol compounds. In the present experiment, the conditions for oxidation of O-benzoylthiamine disulfide (BTDS) were investigated to elucidate the condition and mechanism of TnA formation. It was found that in the case of the oxidation by hydrogen per oxide, the use of lower fatty acid as the solvent gave higher yields but the reaction proceeded fairly well in an aqueous medium. The formation of TnA was also observed by the use of some other oxidizing agents.

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تاریخ انتشار 2009